Alexis Karagianis, APRN

Alexis Karagianis, APRN

Family Nurse Practitioner

37026 US Highway 19 N
Palm Harbor, FL 34684

Overall rating

Top reviews

Alexis was very open and patient friendly. I was there for a second opinion and so glad I did. She gave me hope that my problem can be addresses. She saw my xray, then ordered an MRI to get additional information and laid out pShow moreossible scenarios based on what will be learned. Positivity, and information gives us power! None of this was done by original Ortho who had basically dismissed me and said get used to it. With Alexis were starting a path forward.

Lois P. • October 13, 2026

I always have a good visit with PA Alexis at Ortho Specialists She is knowledgeable, takes the time to listen to my concerns, explains everything clearly and makes me feel comfortable throughout my visit I truly appreciate her proShow morefessionalism, compassion and excellent care I highly recommend Orthopedic Specialists The doctors, technicians and staff are amazing

Lynn W. • July 17, 2026

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About Alexis Karagianis, APRN

Alexis Karagianis, FNP, APRN, is a family nurse practitioner specializing in orthopedics at Orthopedic Specialists in Palm Harbor, Florida. She has nearly a decade of experience working alongside orthopedic physicians in both clinical and hospital settings. 

Alexis’s healthcare journey began at Orthopedic Specialists, where she worked as a scribe/medical assistant while completing nursing school, and she continued to assist as needed throughout her time as a practicing nurse. Her long-standing collaboration with the physicians at Orthopedic Specialists has given her a deep understanding of orthopedic care and a strong continuity of practice.

She gained additional experience as a registered nurse on the medical-surgical floor at St. Joseph’s Hospital, where she developed a broad clinical skill set and a deep commitment to patient-centered care. She later served as an orthopedic nurse at Mease Countryside Hospital, where she honed her expertise in treating complex orthopedic conditions. These roles further sharpened her clinical skills and reinforced her passion for helping patients recover mobility and quality of life.

A proud Tarpon Springs native, Alexis earned both her Bachelor of Science in Nursing and her Master of Science in Nursing, Family Nurse Practitioner from South University. Today, she brings a warm, evidence-based approach to treating orthopedic conditions, combining years of experience with a deep commitment to patient-centered care.


Services, Conditions and Procedures

Little League Elbow

Cubital Tunnel Syndrome

Distal Biceps Tendon Rupture

Elbow Arthritis

Elbow Arthroscopy

Elbow Bursitis

Elbow Fractures

Elbow Ligament Injuries

Golfer’s Elbow

Tennis Elbow

ACL

Labral Tear

Shoulder Arthritis

Shoulder Impingement

Shoulder Tendinitis

Dislocated Shoulder/Shoulder Instability

Chondromalacia

MCL/LCL/PCL Tears

Meniscus Tear

Patellofemoral Pain Syndrome

Synovitis

ACL Injury

Achilles Tendinitis

Ankle Arthritis

Ankle Sprain

Osteochondral Lesion of the Talus (OLT)

Plantar Fasciitis

Foot and Ankle Osteoarthritis

Hallux Rigidus (Big Toe Arthritis)

Midfoot Arthritis

Carpal Tunnel Syndrome

Dupuytren’s Contracture

Trigger Finger

Avascular Necrosis

Hip Bursitis

Hip Labral Tear

Hip Tendinitis

Wrist Ganglion Cyst

deQuervain’s tendonitis

Hip Osteoarthritis

Ankle Pain

Ankle/Foot

Anterior Total Hip Replacement

Arthritis

Arthroscopic Surgery

Back Pain

Cervical Epidural Steroid Injection

Cervical Medial Branch Block

Cervical Radiculopathy

Cortisone Injections

Degenerative Disc Disease

Fractures

Frozen Shoulder

Herniated Disc

Injections

Joint Instability

Knee Pain

Lumbar Medial Branch Block

Lumbar Radiofrequency Ablation

Lumbar Sympathetic Block

Lumbar Transforaminal Epidural Steroid Injection

MRI

Minimally Invasive Joint Replacement

Motor Vehicle Accidents

Neck Pain

Hip Pain

Non-Operative Pain Treatment

Occipital Nerve Block

PRP

Physical Therapy

Robotic Assisted Surgery

Robotic Total Knee Replacement

Rotator Cuff

Sacroiliac Joint Injection

Sciatica

Shoulder Replacement

Specialty Guided Injections

Sports Medicine

Sprains

The Stem Cell Therapy

Joint Replacement

Sports Physicals Orthopedics

Trigger Point Injections

Cervical and Lumbar Radiculopathy

Young Athletes Sports Injuries

Bursitis and Tendinitis

Osteoarthritis

Worker's Compensation

Elbow

Spinal Stenosis

Spine Surgery

Facet Syndrome

Hand & Wrist Pain

Femoroacetabular Impingement (FAI)

Hip Arthroscopy

In-Office Trigger Finger Release

Ligament Reconstruction of Wrist and Elbow


Location

Orthopedic Specialists

37026 US Highway 19 N
Palm Harbor, FL, 34684


More About Alexis Karagianis, APRN

Practice

Orthopedic Specialists

Specialties

  • Family Nurse Practitioner
  • Nurse Practitioner

NPI Number

1043088065

Provider's Gender

Female


Reviews

4.93
831 Reviews

Alexis was very open and patient friendly. I was there for a second opinion and so glad I did. She gave me hope that my problem can be addresses. She saw my xray, then ordered an MRI to get additional information and laid out possible scenarios based on what will be learned. Positivity, and information gives us power! None of this was done by original Ortho who had basically dismissed me and said get used to it. With Alexis were starting a path forward.

Lois P. • October 13, 2026

She is very thorough !!

Richard K. • October 13, 2026

Alexis was extremely professional. She was a pleasure to talk to. She asked numerous times if I had questions, which I did, and she explained everything to my satisfaction. I highly recommend Alexis and this office.

James R. • October 12, 2026

Alexis was great !

Vincent V. • October 08, 2026

Alexis is fantastic and explains everything.

Betty M. • October 07, 2026

Very friendly, experienced,intuitive, compassionate , and listens and seems to really takes pride in her work … very approachable and a critical thinker … good w the patient… love going to her because we can tell her our needs and she prides herself in resolving them … not dismissing them …

Charlotte J. • October 05, 2026

Good

David P. • October 02, 2026

Intelligent professional. Had several suggestions for my intended care. Will be back in several weeks for follow up

Michael S. • October 02, 2026

Very polite, professional willing to listen and even make suggestions. Answered all my questions fully completely satisfied with her evaluation.

James T. • September 15, 2026

Very fast appointment very organized

Nancy T. • September 15, 2026

This office is always easy to work with. Got an appointment timely. Alexis, APRN, is awesome! Really listened and took time to address my concerns. Thank you!

Patricia A. • September 15, 2026

Excellent care. Was treated with respect. At my age, I admire patients Thank you and your staff.

Carmen G. • September 10, 2026

Very thorough and professional. Steroid injection for my painful shoulder. Relief today= strengthening with PT so I can return to work soon

Michelle V. • September 05, 2026

Place was awesome! as big as walmart! Staff very nice. Short wait time. Clean bathrooms.alexis very informative. Will recommend. Thank you for a great visit!

Karen M. • September 05, 2026

Very quick & professional has expected thank you

Stephen B. • August 31, 2026

Wonderful...Alexis is great! She is so smart, knowledgeable, caring...wanting to help! I thank God that he sent her to me!

Lauren E. • August 28, 2026

Alexis pays attention to our concerns and answers any questions we have. She considers all options and provides good information.

Robert C. • August 27, 2026

Alexis is the best

Jay T. • August 27, 2026

Extremely professional and well versed

Alfonso P. • August 27, 2026

Alexis very knowledgeable and informative of my condition while iam on road to recovery

Robert D. • August 20, 2026

Very knowledgeable. Very professional. Very friendly

Matthew C. • August 19, 2026

Alexis was very knowledgeable about my condition and explained my treatment options thoroughly. I am very pleased with the treatment options and look forward to working with Alexis in the future.

James M. • August 19, 2026

Listens carefully and recommends the best treatment for my personal condition.

Martha C. • August 19, 2026

Alexis takes the time to listen to her patients and is very knowledgeable.

Ruth F. • August 18, 2026

Alexis is a great PA! She listens well, very professional, and caring. Everyone at that practice is wonderful.

Michael S. • August 13, 2026

She is attentive takes her time to explain results and a great listener. Would highly recommend her to anyone

Pamela O. • August 12, 2026

I was there reviewing MRI result & options for treatment. Everything was explained clearly & will be starting physical therapy.

Michael M. • August 08, 2026

Very attentive and seemed to care about my discomfort.

Anne K. • August 07, 2026

Always on time. Takes the time to answer any questions. Very through.

Leslie C. • July 31, 2026

Very pleasant to deal with very experienced in her knowledge of understanding your particular circumstance, and very helpful with her knowledge of being able to answer your questions

Vincent M. • July 25, 2026

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