Alexis Karagianis, APRN, Family Nurse Practitioner

Alexis Karagianis, APRN

Family Nurse Practitioner

37026 US Highway 19 N
Palm Harbor, FL 34684

Overall rating

Top reviews

Alexis is so great at explaining in detail as well as showing you the areas she is talking about on your body. She takes her time in explaining the exrays and MRI’s so you completely know what she is talking about. She makes suggShow moreestions and gives advice for helping cope with the pain and whatever else is going on with you. She is not pushy and listens to what you tell her. I was very pleased with my appointment with her.

Rosemary S. • July 10, 2026

I always have a good visit with PA Alexis at Ortho Specialists She is knowledgeable, takes the time to listen to my concerns, explains everything clearly and makes me feel comfortable throughout my visit I truly appreciate her proShow morefessionalism, compassion and excellent care I highly recommend Orthopedic Specialists The doctors, technicians and staff are amazing

Lynn W. • July 17, 2026

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About Alexis Karagianis, APRN

Alexis Karagianis, FNP, APRN, is a family nurse practitioner specializing in orthopedics at Orthopedic Specialists in Palm Harbor, Florida. She has nearly a decade of experience working alongside orthopedic physicians in both clinical and hospital settings. 

Alexis’s healthcare journey began at Orthopedic Specialists, where she worked as a scribe/medical assistant while completing nursing school, and she continued to assist as needed throughout her time as a practicing nurse. Her long-standing collaboration with the physicians at Orthopedic Specialists has given her a deep understanding of orthopedic care and a strong continuity of practice.

She gained additional experience as a registered nurse on the medical-surgical floor at St. Joseph’s Hospital, where she developed a broad clinical skill set and a deep commitment to patient-centered care. She later served as an orthopedic nurse at Mease Countryside Hospital, where she honed her expertise in treating complex orthopedic conditions. These roles further sharpened her clinical skills and reinforced her passion for helping patients recover mobility and quality of life.

A proud Tarpon Springs native, Alexis earned both her Bachelor of Science in Nursing and her Master of Science in Nursing, Family Nurse Practitioner from South University. Today, she brings a warm, evidence-based approach to treating orthopedic conditions, combining years of experience with a deep commitment to patient-centered care.


Services, Conditions and Procedures

Little League Elbow

Cubital Tunnel Syndrome

Distal Biceps Tendon Rupture

Elbow Arthritis

Elbow Arthroscopy

Elbow Bursitis

Elbow Fractures

Elbow Ligament Injuries

Golfer’s Elbow

Tennis Elbow

ACL

Labral Tear

Shoulder Arthritis

Shoulder Impingement

Shoulder Tendinitis

Dislocated Shoulder/Shoulder Instability

Chondromalacia

MCL/LCL/PCL Tears

Meniscus Tear

Patellofemoral Pain Syndrome

Synovitis

ACL Injury

Achilles Tendinitis

Ankle Arthritis

Ankle Sprain

Osteochondral Lesion of the Talus (OLT)

Plantar Fasciitis

Foot and Ankle Osteoarthritis

Hallux Rigidus (Big Toe Arthritis)

Midfoot Arthritis

Carpal Tunnel Syndrome

Dupuytren’s Contracture

Trigger Finger

Avascular Necrosis

Hip Bursitis

Hip Labral Tear

Hip Tendinitis

Wrist Ganglion Cyst

deQuervain’s tendonitis

Hip Osteoarthritis

Ankle Pain

Ankle/Foot

Anterior Total Hip Replacement

Arthritis

Arthroscopic Surgery

Back Pain

Cervical Epidural Steroid Injection

Cervical Medial Branch Block

Cervical Radiculopathy

Cortisone Injections

Degenerative Disc Disease

Fractures

Frozen Shoulder

Herniated Disc

Injections

Joint Instability

Knee Pain

Lumbar Medial Branch Block

Lumbar Radiofrequency Ablation

Lumbar Sympathetic Block

Lumbar Transforaminal Epidural Steroid Injection

MRI

Minimally Invasive Joint Replacement

Motor Vehicle Accidents

Neck Pain

Hip Pain

Non-Operative Pain Treatment

Occipital Nerve Block

PRP

Physical Therapy

Robotic Assisted Surgery

Robotic Total Knee Replacement

Rotator Cuff

Sacroiliac Joint Injection

Sciatica

Shoulder Replacement

Specialty Guided Injections

Sports Medicine

Sprains

The Stem Cell Therapy

Joint Replacement

Sports Physicals Orthopedics

Trigger Point Injections

Cervical and Lumbar Radiculopathy

Young Athletes Sports Injuries

Bursitis and Tendinitis

Osteoarthritis

Worker's Compensation

Elbow

Spinal Stenosis

Spine Surgery

Facet Syndrome

Hand & Wrist Pain

Femoroacetabular Impingement (FAI)

Hip Arthroscopy

In-Office Trigger Finger Release


Location

Orthopedic Specialists

37026 US Highway 19 N
Palm Harbor, FL, 34684


More About Alexis Karagianis, APRN

Practice

Orthopedic Specialists

Specialties

  • Family Nurse Practitioner
  • Nurse Practitioner

NPI Number

1043088065

Provider's Gender

Female


Reviews

4.93
816 Reviews

Wonderful...Alexis is great! She is so smart, knowledgeable, caring...wanting to help! I thank God that he sent her to me!

Lauren E. • August 28, 2026

Alexis pays attention to our concerns and answers any questions we have. She considers all options and provides good information.

Robert C. • August 27, 2026

Alexis is the best

Jay T. • August 27, 2026

Extremely professional and well versed

Alfonso P. • August 27, 2026

Alexis very knowledgeable and informative of my condition while iam on road to recovery

Robert D. • August 20, 2026

Very knowledgeable. Very professional. Very friendly

Matthew C. • August 19, 2026

Alexis was very knowledgeable about my condition and explained my treatment options thoroughly. I am very pleased with the treatment options and look forward to working with Alexis in the future.

James M. • August 19, 2026

Listens carefully and recommends the best treatment for my personal condition.

Martha C. • August 19, 2026

Alexis takes the time to listen to her patients and is very knowledgeable.

Ruth F. • August 18, 2026

Alexis is a great PA! She listens well, very professional, and caring. Everyone at that practice is wonderful.

Michael S. • August 13, 2026

She is attentive takes her time to explain results and a great listener. Would highly recommend her to anyone

Pamela O. • August 12, 2026

I was there reviewing MRI result & options for treatment. Everything was explained clearly & will be starting physical therapy.

Michael M. • August 08, 2026

Very attentive and seemed to care about my discomfort.

Anne K. • August 07, 2026

Always on time. Takes the time to answer any questions. Very through.

Leslie C. • July 31, 2026

Very pleasant to deal with very experienced in her knowledge of understanding your particular circumstance, and very helpful with her knowledge of being able to answer your questions

Vincent M. • July 25, 2026

Awsome

Robert K. • July 23, 2026

I always have a good visit with PA Alexis at Ortho Specialists She is knowledgeable, takes the time to listen to my concerns, explains everything clearly and makes me feel comfortable throughout my visit I truly appreciate her professionalism, compassion and excellent care I highly recommend Orthopedic Specialists The doctors, technicians and staff are amazing

Lynn W. • July 17, 2026

Such a Nice person, extremely professional and listening to what ever your issues are. I definitely would recommend her to anyone in need

Robert P. • July 16, 2026

Very professional and care about my wrist issue. Presented a path towards the cure which should result in full recovery.

Paul J. • July 14, 2026

Alexis is so great at explaining in detail as well as showing you the areas she is talking about on your body. She takes her time in explaining the exrays and MRI’s so you completely know what she is talking about. She makes suggestions and gives advice for helping cope with the pain and whatever else is going on with you. She is not pushy and listens to what you tell her. I was very pleased with my appointment with her.

Rosemary S. • July 10, 2026

She is an example of what the position demands. Very polite, professional, & the dedication to her patients shows.

Eric H. • July 10, 2026

Alexis was great at listening to the issue I’m having. We discussed different options for resolving my issues with my knee. We decided on medication to try and relieve the pain I am experiencing. I would strongly recommend this practice.

Shirley H. • July 06, 2026

Alexis has absolutely amazing. She has taken such a personal interest in my care. She went well above and beyond to check in on me on multiple occasions while I was recovering from surgery. It truly meant a lot to me when I looked up and saw her pop in my room to see how I was recovering. She's a rockstar. Thanks for everything.

Terry R. • July 03, 2026

She did ana amazing job with the cortisone shots in both knees!

David K. • June 19, 2026

Excellent practitioner she listens. I would recommend her to everyone. Orthopedic Specialists is the best

Kimberly S. • June 19, 2026

Alexis is very thorough. She listened to my concerns and explained things in a way I understood.

Carolyn M. • June 18, 2026

informative and detailed. she answered all my questions with no hesitation.

Shaun S. • June 15, 2026

Very professional and she was able to explain next steps in a clear method so I was able to understand. She made me feel at ease and took away my concerns.

Kay G. • June 10, 2026

First time here and had a great experience with almost everyone we met.

Sharon C. • June 03, 2026

It is clear every associate there has lots of experience and lots of confidence. They are very efficient and they all work well together to take care of their patients. Checking in and checking out is a breeze!

Gloria I. • June 02, 2026

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